Description
CTNNB1(S37Y) 单抗
| 货号: 26296 |
| 基因符号: CTNNB1 |
| 描述: Anti-CTNNB1(S37Y) Mouse Monoclonal Antibody |
| 背景介绍: CTNNB1 protein is a dual function protein. It is a subunit of a complex of proteins that from adherent junctions, which are important for the establishment and maintenance of epithelial cell layers by regulating cell growth and adhesion between adjacent cells. CTNNB1 protein also pulls double duty as an intracellular signal transducer in the Wnt signaling pathway. Mutant CTNNB1 (?-catenin) has been implicated in the pathogenesis of several cancers including melanoma, colorectal cancer, hepatocellular carcinoma, and ovarian cancer. Mutations has been implicated in the pathogenesis of several cancers. |
| 免疫原: A synthetic peptide from the internal region of CTNNB1, which includes the mutation of S37Y, human origin |
| 经过测试的应用: ELISA, WB, IHC |
| 推荐稀释比: ELISA: 1: 1000-1: 5000 WB: 1: 500-1: 2000 IHC: 1: 50-1: 100 |
| 浓度: 1 mg/ml |
| 宿主: Mouse |
| 形式: Liquid |
| 克隆性: Monoclonal |
| 亚型: IgG |
| 纯度: Purified from ascites |
| 防腐剂: No |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| 种属反应性: Recognizes S37Y mutant, but not wild-type CTNNB1 of vertebrates |
| 储存条件: Store at -20°C. Avoid repeated freezing and thawing |
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蛋白质印迹: Purified His-tagged CTNNB1 (S37Y) protein (lane 2) and corresponding wildtype protein (lane 1) were blotted with Anti-CTNNB1(S37Y) monoclonal antibody (Cat. #26296). |
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