Description
ERBB2(D769Y)
| 货号: 26382 |
| 基因符号: ERBB2/HER2/Neu/c-Neu |
| 描述: Anti-ERBB2(D769Y) Mouse Monoclonal Antibody |
| 背景介绍: The HER-2/neu oncogene, a member of the epidermal growth factor receptor or erb-B gene-like family, encodes a transmembrane tyrosine kinase receptor that mediates extracellular signals activated by epidermal growth factors. Her2 abnormal has been strongly associated with many malignant tumors, especially with breast cancers. The expression level of Her2 is an important criteria in clinic evaluating of the progression of breast cancer. |
| 免疫原: A synthetic peptide from the internal region of ERBB2 which includes the mutation of D769Y, human origin |
| 经过测试的应用: ELISA, IF, IHC |
| 推荐稀释比: ELISA: 1: 1000-1: 2000 IF: 1: 500-1: 1000 IHC: 1: 50-1: 100 |
| 浓度: 1 mg/ml |
| 宿主: Mouse |
| 形式: Liquid |
| 克隆性: Monoclonal |
| 亚型: IgG |
| 纯度: Purified from ascites |
| 防腐剂: No |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| 种属反应性: Recognizes D769Y mutant, but not wild-type ERBB2 of vertebrates |
| 储存条件: Store at -20°C. Avoid repeated freezing and thawing |
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免疫荧光: Immunofluorescence of cells expressing ERBB2 proteins with Anti-ERBB2(D769Y) antibody. HEK293T cells were transfected with pCDNA3-GFP-ERBB2(D769Y) plasmid, pCDNA3-GFP-ERBB2 (WT) plasmid or pCDNA3-GFP-ERBB2 (D769H) plasmid, then fixed and stained with Anti-ERBB2(D769Y) monoclonal antibody (Cat. #26382). |
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