Description
JAK2(R683S) 单抗
| 货号: 26315 |
| 规格: 100 μL |
| 基因符号: JAK2, JTK10, THCYT3 |
| 描述: Anti-JAK2(R683S) Mouse Monoclonal Antibody |
| 背景介绍: JAK2 is a non-receptor tyrosine kinase. It is a number of the Janus kinase family and has been implicated in ssignaling by members of the type II cytokine receptor family, the GM-CSF receptor family, the gp130 receptor family, and the single chain receptors. JAK2 orthologs have been identified in all mammals for which complete genome genome data are available. Mutations of JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders. |
| 免疫原: A synthetic peptide from the internal region of JAK2 which includes the mutation of R683S, human origin |
| 经过测试的应用: ELISA, WB, IHC |
| 推荐稀释比: ELISA: 1: 1000-1: 2000 WB: 1: 500-1: 1000 IHC: 1: 50-1: 100 |
| 浓度: 0.5 mg/ml |
| 宿主: Mouse |
| 形式: Liquid |
| 克隆性: Monoclonal |
| 亚型: IgG |
| 纯度: Purified from ascites |
| 防腐剂: No |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| 种属反应性: Recognizes R683S mutant, but not wild-type JAK2 of vertebrates |
| 储存条件: Store at -20°C. Avoid repeated freezing and thawing |
蛋白质印迹:  Western blot analysis of recombinant JAK2(R683S) and wildtype proteins. Purified His-tagged JAK2(R683S) protein (lane2) and corresponding wild-type protein (lane1) were blotted with Anti-JAK2(R683S) monoclonal antibody (Cat. #26314). |
免疫荧光:  Immunofluorescence of cells expressing JAK2 proteins with Anti-JAK2(R683S) antibody. HEK293T cells were transfected with pCDNA3-GFP-JAK2(R683S) plasmid,pCDNA3-GFP-JAK2 (WT) plasmid, pCDNA3-GFP-JAK2 (R683T) plasmid or pCDNA3-GFP-JAK2 (R683G) plasmid, then fixed and stained with Anti-JAK2(R683S) monoclonal antibody (Cat. #26314). |
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